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Retatrutide activates human GCGR, GIPR, and GLP-1R with EC50 values of 5.79, 0.0643, and 0.775 nM, respectively

Fever with worsening belly pain
If the patient experiences gastrointestinal adverse effects during dose escalation, uptitration can be delayed for an additional week [21]

[DOI] [PubMed] [Google Scholar] 119.Aronne LJ, Sattar N, Horn DB, et al
