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Higher mean age and baseline SBP, greater use of anti-hypertensive medications, longer T2D duration, and reduction in insulin daily dose might have contributed to explain the difference observed in the impact of weight loss on SBP reduction in these trials, although direct GLP-1R- and GIP-R-mediated effects could also be considered [77]

[DOI] [PMC free article] [PubMed] [Google Scholar] 100.Elliott J.A., Docherty N.G., Haag J., Eckhardt H.G., Ravi N., Reynolds J.V., Le Roux C.W

doi: 10.1128/mcb.10.12.6799

It can also result in serious complications, including bezoars, severe dehydration, and unpredictable blood sugar changes

The urine albumin to creatinine ratio fluctuates by 30 to 40% on the basis of several factors, such as the presence of a fever, dehydration, vigorous physical activity or urinary tract infection