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Future Research Goals So far, most evidence comes from retrospective studies or case reports, not from large randomized clinical trials, says Tariq, who says that experts are still looking to understand: Whether GLP-1s directly reduce intestinal inflammation How GLP-1s interact with the immune system and the gut microbiome Whether they are as effective in people with active Crohns disease as with those in remission Current research findings show promise, but Tariq encourages her patients to view them as early signals instead of established treatments