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The identification of peripheral macrophages (Hultman et al., 2013) and neutrophils (Zenaro et al., 2015) in the brain of individuals with AD also suggest a breakdown of the BBB, leading to increased influx of peripheral immune cells into the brain

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56 After 3 years, the primary composite outcome (nonfatal myocardial infarction, nonfatal stroke, or CV death) occurred in fewer patients assigned to the SGLT2-I versus placebo (10.5% vs 12.1%

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