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Their muscle-to-fat ratio usually still improves, but in particularly vulnerable populations, such as older adults, rapid and significant muscle loss can be a dangerous issue

Long-Term Weight Loss & Maintenance with Semaglutide in Obesity (2022 Review of STEP Trials) consolidates findings across multiple STEP trials (1, 3, 4, 8), showing 14.917.4% mean weight loss over 68 weeks, improved cardiometabolic markers, and better quality-of-life outcomes

longum) are well-studied for reducing gas and bloating in people with IBS and other digestive conditions

Cardiovasc Diabetol 2019

However, because it is a stimulant, it is not recommended for patients with a history of substance abuse