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Data from a phase 1 feasibility trial showed that treatment of adults with early-stage AD with a combination of dasatinib and quercetin was well tolerated, and promising results from an exploratory analysis indicated the potential reduction of inflammatory markers (Gonzales et al., 2023) consistent with responses observed in preclinical studies (Zhang et al., 2019b)

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Increased adiposity drives insulin resistance The prevalence of insulin resistance and type 2 diabetes has experienced a significant surge within the US population in the past 20 years

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The trial participants also showed cardiovascular improvements after taking orforglipron, including lower systolic blood pressure, lower non-HDL cholesterol and lower triglycerides