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Sitagliptin, the first approved DPP-4 inhibitor, was developed by a group led by Nancy Thornberry and Ann Weber at Merck and lowered HbA1c by ~0.8% as a monotherapy with a highly significant reduction of ~1.9% when icombined with metformin (1)

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In the recently published SURPASS-6 trial, 1428 patients with T2DM using basal insulin were randomized to either prandial insulin Lispro, 5 mg, 10 mg, or 15 mg of once-weekly tirzepatide for 52 weeks

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