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Support for this hypothesis comes from the finding that, in ovariectomized rats, estradiol replacement enhances peripheral GLP-1 induced suppression on food intake (199, 200)

Effect of portal glucose sensing on systemic glucose levels in SD and ZDF rats

However, NICE also highlights that certain groupssuch as women, older adults, and Black individualsare less likely to receive these medications

In particular, the studies only enlisted people who previously failed dieting and also recruited people at the 95th percentile for BMI

*Correspondence: Arjola Bano, [email protected] These authors have contributed equally to this work This article was submitted to Cardiovascular and Smooth Muscle Pharmacology, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers