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Li B, Goss D, Miller JW
Participants with class III obesity (BMI 40 or higher) were more likely to be late responders, meaning they needed more time to achieve significant weight loss

Am J Gastroenterol 2001;97:S255

For example, a 72-week phase II trial involving 320 patients with MASH, reported MASH resolution rates of up to 59% at the highest dose of 0.4 mg daily as compared to 17% in the placebo group

To a large extent, these changes are also characteristic of metabolic syndrome, which affects approximately 25% of the worlds adult population and is associated with insulin resistance, hypertension, dyslipidemia and obesity, factors that increasingly lead to cognitive impairment and brain atrophy
