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The Ala scan revealed the N-terminal (position 7, 8, 9, 10, 12, 13, and 15), as well as specific amino acids toward the C-terminal (position 28 and 29), to be crucial for the activity of GLP-1

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Based on above results, we speculated that the change in glucose homeostasis observed after T3 treatment in hypothyroid mice is likely attributed to the chronic rather than acute effect of T3

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Proceedings of the National Academy of Sciences of the United States of America, 84 (10), 34343438