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Naunyn-Schmiedeberg's Arch Pharmacol 392 , 13211330 (2019)

Additional comparative evidence comes from: A 2025 narrative review synthesising randomised and indirect comparison data across obesity and type 2 diabetes trials, confirming tirzepatides superiority on weight and HbA1c [2]

C., Celsi, G

A significant reduction in pro-inflammatory molecules, including C-reactive protein (CRP), TNF- , and IL-6, was observed, indicating the inhibition of inflammatory pathways, likely at the level of immune system cells and adipocytes signaling