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Discovery of gastric inhibitory polypeptide (GIP) Among those active in the field was John Brown (figure 16), a British-born physiologist, who developed a passion for the gastrointestinal gut while doing a doctorate at the University of Newcastle-upon-Type

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[DOI] [PubMed] [Google Scholar] 78.Ban K, Noyan-Ashraf MH, Hoefer J, Bolz SS, Drucker DJ, Husain M

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Attributed to the selective IR paradox, compensatory hyperinsulinemia can amplify hyperandrogenism via several mechanisms: (i) cross-activation of insulin and/or IGF-1 receptors, which enhances LH-mediated expression of key steroidogenic enzymes (e.g., CYP17A1) in ovarian theca cells and increases androgen synthesis