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Estimated hazard ratio for 6 mg/weekly dose of efpeglenatide compared to placebo was 0,65 (95% CI, 0.5 to 0.86) and 0.82 (95% CI 0.63 1.06) for 4 mg/weekly dose compared to placebo (44)
Early data shows improvements in cardiovascular risk markers (cholesterol, blood pressure, inflammation), but these are surrogate endpoints, not proven event reduction
PLoS ONE 2010
While further breakthroughs remain necessaryparticularly in standardizing preparation protocols and evaluating long-term efficacythis work establishes a crucial theoretical framework for developing clinical-grade, multifunctional probiotic combinations with enhanced targeting capabilities
Patients may notice lower energy levels early in treatment due to reduced calorie intake
