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The biotech firm Metsera, which is developing a once-monthly GLP-1 injection, became the object of a bidding war between Pfizer and Novo Nordisk, with Pfizer emerging as the winner

Semaglutide provides similar though slightly less potent effects than tirzepatide
A few highlights: Accelerated eGFR decline during the year preceding a heart failure event Slower decline afterward but still exacerbated A parallel between eGFR slope and NYHA class, suggesting the kidney may be signaling congestion early These findings call for a shift in practice: instead of relying on static eGFR thresholds, tracking its trajectory over time could help us identify at-risk patients sooner and intervene before hospitalization
Others stay on them indefinitely
Danne T, Garg S, Peters AL et al (2019) International consensus on risk management of diabetic ketoacidosis in patients with type 1 diabetes treated with sodium-glucose cotransporter (SGLT) inhibitors