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The biotech firm Metsera, which is developing a once-monthly GLP-1 injection, became the object of a bidding war between Pfizer and Novo Nordisk, with Pfizer emerging as the winner

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Semaglutide provides similar though slightly less potent effects than tirzepatide

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A few highlights: Accelerated eGFR decline during the year preceding a heart failure event Slower decline afterward but still exacerbated A parallel between eGFR slope and NYHA class, suggesting the kidney may be signaling congestion early These findings call for a shift in practice: instead of relying on static eGFR thresholds, tracking its trajectory over time could help us identify at-risk patients sooner and intervene before hospitalization

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Others stay on them indefinitely

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Danne T, Garg S, Peters AL et al (2019) International consensus on risk management of diabetic ketoacidosis in patients with type 1 diabetes treated with sodium-glucose cotransporter (SGLT) inhibitors

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