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The predicted weight reduction for each cohort was then used to predict the effect sizes for the primary endpoints in the OSA and OA baskets independently, acknowledging that this approach could underestimate weight lossindependent or drug mechanismdependent effects, which may additionally contribute to efficacy

Spicy Food: Some people find that spicy foods worsen nausea

A phase 2b clinical trial to evaluate the safety and efficacy of GR-MD-02 for the treatment of liver fibrosis and resultant portal hypertension in 162 patients with NASH cirrhosis (NASH-CX trial) is now ongoing (NCT02462967)

This is specifically stated in many product information leaflets and is not merely a matter of convenience
