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Materials and methods Literature search and search strategy Searches were conducted in a comprehensive manner for publications of relevant peer-reviewed papers and dissertations between 1990 and 2022 in the Embase, PubMed, Cochrane Library, China National Knowledge Infrastructure (CNKI), Wanfang Data Knowledge Service Platform, and Weipu website (VIP) databases for all clinical studies on GLP-1 interventions in AD without language restrictions, using the Medical Subject Headings (MeSH) terms such as glucagon-like peptide 1, Alzheimers disease and cognitive function

Future research should focus on integrating advanced retinal models, synergistic treatment regimens, and rigorous clinical trials to harness the therapeutic potential of GLP-1RAs fully

This is why initial side effects often include symptoms like nausea, bloating and constipation

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While not direct drug side effects, these changes occur in the context of treatment and may be perceived as medication-related