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This resistance can arise from a weak immune response within the tumor, reduced surface MHC expression, and dysfunctional interferon-gamma (IFN-) signaling, all of which contribute to a cold tumor microenvironment (TME) characterized by limited T cell presence
The fact that the cecal contents of RETA-w/d mice are not different than Veh controls demonstrates that RETA withdrawal was effective as the half-life in mice is 21 h 32
Clinicians should also consider access and affordability as part of routine diabetes care
