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Drug discontinuation due to side effects was 10% at the 15 mg dose, the highest of any dose

Albala et al

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Nutritional Optimization Despite reduced appetite, maintaining adequate nutrition is essential: Ensure sufficient caloric intake : Work with a healthcare provider or registered dietitian to establish appropriate caloric goals that support gradual, healthy weight loss without excessive restriction Prioritize protein : During weight loss, aim for approximately 1.0-1.2 grams of protein per kilogram of body weight daily to preserve lean muscle mass (patients with kidney disease should follow their provider's specific recommendations) Focus on nutrient density : Choose foods rich in vitamins, minerals, and complex carbohydrates to support energy levels Eat smaller, frequent meals : This approach may be better tolerated given semaglutide's effect on gastric emptying Hydration and Electrolyte Balance Adequate fluid intake is crucial, particularly if experiencing gastrointestinal side effects