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Advances in Nutrition, 8(3), 511519

By pre-treating rats with the non-specific cholinergic receptor antagonist atropine as well as the specific M3 cholinergic receptor antagonist 4-DAMP and performing vagotomy, the researchers found that atropine and 4-DAMP significantly reduced metformin-induced GLP-1 secretion, whereas vagotomy had no effect on metformin-induced GLP-1 secretion

Its also beneficial to write down questions you may have and bring them to your appointment

Using a drug with no safety data in a population with a condition that already requires precise glucose management is a serious risk

Therefore, SYMLIN and insulin must always be administered as separate injections and should never be mixed [see Drug Interactions (7.1) and Clinical Pharmacology (12.3)]