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3.3 Tirzepatide effects: cardiovascular, renal, hepatic, and other metabolic effects of tirzepatide Due to concerns that type 2 diabetes medications increased cardiovascular risk, the FDA issued guidance for pharmaceutical companies to perform cardiovascular outcomes trials for new diabetes medications

Baz M, Boivin G

However, there was no association between GLP1RAs and reduced risk of postmenopausal breast cancer and no clear difference in breast cancer incidence among postmenopausal women treated with GLP1RAs compared to those treated with insulin or metformin [87]

They work by inhibiting the DPP-4 enzyme, which is responsible for degrading incretin hormones

A total of 51 studies fulfilled the inclusion criteria
