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A decreased glucose uptake in the hippocampus, parietal cortex and posterior cingulate cortex has been observed in early AD (Protas et al., 2013)

The EU recognises this distinction

antihistamines (e.g., chlorpheniramine, due to sedation and anticholinergic load), certain benzodiazepines and sedatives (possible enhanced sedative or hypotensive effects), and sympathomimetics (risk of hypertension) have all been noted as interactions in drug databases

For example, IQVIA data suggests privately paid use of AOMs by almost 100,000 patients in Germany

Clinical audiences are equally impressed with the data, hailing a new era for how obesity is perceived and treated, notwithstanding the missed statistical significance for cardiovascular death and the other secondary confirmatory endpoints not being tested for superiority as a consequence