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Description
Its receptor binding profile shows that it binds to GIP receptors with an affinity similar to the natural hormone but has a fivefold lower affinity for GLP-1 receptors
Applications: Semaglutide is commonly used in preclinical studies exploring metabolic pathways, GLP-1 receptor activation, and energy balance models.
Cognition improved in exenatide treated patients in fluid intelligence (baseline 38.4 (8.2), 12 weeks 52.9 (6.6), p=0.0005), processing speed (baseline 43.7 (9.4), 12 weeks 58.4 (10.4), p=0.0058) and episodic memory (baseline 49.4 (5.3), 12 weeks 62.1 (13.2), p=0.0315)
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