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doi:10.1161/01.cir.0000025242.79963.4c DOSE trial: Felker GM, Lee KL, Bull DA, et al

Starting at too high of a dose or increasing the dose too quickly can lead to symptoms such as indigestion, nausea, vomiting, diarrhea, or constipation

She spends most of her time in bed with low daily physical activity and has experienced more weakness and exhaustion over the past year along with loss of muscle mass

16 Since it influences multiple systems of the body along with their functionsincluding digestion, blood sugar metabolism, and how the body processes energyits impact on health is broad, and requires thoughtful consideration

If a patient is on a much higher dose, they have an increased risk for more significant side effects with long term use," he said