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Description
Other tiers you will see below: Moderate (one solid trial or a consistent real-world pattern), Emerging (early or contested signals), and Mechanistic Only (animal or lab work with no human data yet)

Layton A, Thiboutot D

It also improved multiple cardiometabolic markers, including cholesterol, blood pressure, inflammation and waist size

10.1056/NEJMoa2302392

Gastroenterology 94 , 10531062 (1988)
