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Here's how they stack up, so you and your provider can settle on the right fit

The big takeaway: retatrutide has similar GI side effects to semaglutide and tirzepatide, but with two unique additions -- dysesthesia (the skin sensitivity thing) and a slightly higher heart rate increase

[PubMed] [Google Scholar] 787.Sengupta K., Long K.J., Allen D.O

Working looks like more regular, easier bowel movements, fewer urgent loose stools, and less day-to-day bloating

Cells within passages 5-10 were used for all experiments