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Diabetes mellitus (DM) significantly increases the risk of cardiovascular diseases and the overall and cardiovascular mortality, and it is a pro-atherogenic factor that induces atherosclerosis development and/or accelerates its progression through a multifactorial process

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51 , 52 Consistent with the preclinical findings, the phase 1 trial demonstrated a dose-dependent reduction in body weight with oral amycretin over a 12-week treatment period, with participants experiencing an average body weight loss of 13.1% at a dose of 2 50 mg