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Most patients experience some degree of delayed emptying during GLP-1 initiation, but this does not constitute gastroparesis unless symptoms are severe, persistent, and confirmed by objective testing

It is essential not to attribute significant, unexpected weight loss solely to GLP-1 RAs without further enquiry

These genes include MKRN3 , MAGEL2 , NDN , and the bicistronic SNURF-SNRPN , as well as C15orf2/NPAP1, a gene that is expressed from both alleles in the testis but only from the paternal allele in the brain ( The MKRN3 gene encodes a protein that belongs to a family of zinc finger proteins that act as an E3 ubiquitin ligase

The key to sustainable weight management is personalization