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doi: 10.1016/S0140-6736(23)01200-X 11 JastreboffAMAronneLJAhmadNNWhartonSConneryLAlvesBet al

In other words, once obesity has set in for a long time, these mechanisms make it very difficult to return to a lower weight

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?, Human) = ~5.4 nM Biological Activity Tirzepatide promotes glucose-dependent insulin secretion, reduces glucagon during hyperglycemia, increases satiety, reduces food intake, and lowers body weight

This shift has encouraged healthcare providers to prescribe anti-obesity medications more readily, particularly for patients with obesity-related comorbidities
