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*adapted from American Diabetes Association 2024 Standards of Care in Diabetes Available GLP-1 Receptor Agonists (GLP-1 RA) The Table below compares currently available GLP-1RA formulations, notes on their dosing and administration schedule, adjustments and demonstrated cardiorenal benefits

Ahern T, Tobin AM, Corrigan M, et al

doi: 10.3389/fendo.2022.891297 127 ChangZPDengGFShaoYYXuDZhaoYNSunYFet al

4,6 A key issue in the physiology of type 2 diabetes (T2DM) is the reduced incretin effect, which mainly results from decreased activity of the primary incretin hormones, GLP-1 (glucagon-like peptide 1) and GIP (glucose-dependent insulinotropic peptide)

Stahl EP, Dhindsa DS, Lee SK, Sandesara PB, Chalasani NP, Sperling LS (2019) Nonalcoholic fatty liver disease and the heart: JACC state-of-the-art review