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Semaglutide, liraglutide, and dulaglutide have demonstrated cardiovascular benefits in clinical trials, with Wegovy (semaglutide 2.4 mg) recently receiving FDA approval for cardiovascular risk reduction in adults with established cardiovascular disease and obesity

however, taspoglutide (long-acting glucagon-like peptide 1 receptor agonist) had by far the highest rates of nausea: 53% and 59% with 10 and 20 mg once weekly, respectively, compared with 35% among participants treated with exenatide twice daily

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Detailed diet plans optimized for GLP-1 therapy focus on protein intake of 1.0-1.2 grams per kilogram of body weight daily, adequate fiber for gut health and satiety, and micronutrient-dense foods to prevent deficiency