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The mean age across all cohorts was 56.55 years, ranging from 47 to 69.5 years

doi: 10.1001/jamaophthalmol.2024.2296 [DOI] [PMC free article] [PubMed] [Google Scholar] 5.Klonoff DC, Hui G, Gombar S

From 2008-2010, Sanofi-Aventis Acomplia (selective CB1 antagonist) and Abbott Laboratories Meridia (NE/5-HT reuptake inhibitor)--both also designed to suppress appetite--were pulled from the market over similar cardiac safety concerns
Another possibility of the direct effects of GLP-1 and ghrelin in the brain has been proposed since both peptides cross the brain blood barrier 25,35

Over time, this can create gaps in essential nutrients like vitamin B12, magnesium, calcium, and vitamin Dall of which play critical roles in maintaining energy, bone health, muscle function, and immune health