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These changes can make the drug less effective, which is why FDA-approved drugs are often better, as the manufacturers must follow strict rules to make sure each dose is the same

N Engl J Med (2008) 359(15):157789

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However, the ongoing lawsuit by OFA, filed on February 24, 2025, challenges the FDA's removal of Semaglutide from the shortage list, alleging procedural violations under the Administrative Procedure Act (GLP-1 Drugs: FDA Removes Semaglutide)

It's also worth noting that saturated fats are known to raise LDL ("bad") cholesterol levels, which can increase the risk of heart disease