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In addition, pharmacological activation of central GLP-1 receptor (GLP-1R) signaling expressed by serotonergic neurons [110112] augments the activity of thermogenic adipose tissue and enhances the utilization of circulating glucose and triglycerides [113, 114]

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32 Additionally, the impact on skeletal muscle mass and quality will be important to establish given the potential for sarcopenia in this HF population

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A few could undermine the therapeutic benefits entirely

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