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Similar to E2, 4-OHT stimulated the proliferation of both MCF-7/ER36 cells and MDA-MB 436 cells transfected with control shRNA (MDA-MB 436/shControl) (Figure 3B and 3C and Supplementary information, Figure S4A), but interestingly, 4-OHT lost the enhancement effects on proliferation of MDA-MB 436/shER36 cells (Figure 3C and Supplementary information, Figure S4B), suggesting that the positive effect of tamoxifen on tumor growth might require ER36

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We summarize the clinical and preclinical evidence that includes evaluations on taste perception under GLP-1RAs treatment in Tables 2 and 3

doi: 10.1017/S1478951512000636 90 PalombaS

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