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Further complicating the issue is the uncertainty surrounding future benefits

[DOI] [PMC free article] [PubMed] [Google Scholar] 133.Rosenstock J, Wysham C, Fras JP, Kaneko S, Lee CJ, et al

This was a double-blind study, meaning neither the researchers nor the patients knew which treatment they were receiving

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These include unexplained fatigue or energy changes, significant mood alterations, palpitations or irregular heartbeat, increased sensitivity to heat or cold, changes in bowel habits beyond expected medication side effects, unexplained hair loss, or skin changes
