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Therefore, the initial demonstrations of a glucose-lowering effect of GLP-1 used continuous i.v
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First, it can make dosing inaccurate

In August 2024, Eli Lilly & Company announced the positive outcomes of the SURMOUNT-1 trial, indicating that Tirzepatide (marketed as Zepbound and Mounjaro) decreased the risk of developing type 2 diabetes by 94% in individuals with prediabetes, obesity, or overweight

Confirmatory trials are needed to confirm clinical benefit for these drugs to remain on the market
