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Skyes CB1 Inhibitor, Nimacimab, Demonstrates Superior Weight Loss and Differentiated Mechanisms from Monlunabant, and Continues to Show Enhanced Combination with Tirzepatide with Durable Post-Treatment Weight Maintenance in DIO Model Skye shares new preclinical DIO data at virtual KOL event Nimacimab + tirzepatide demonstrates over 40% weight loss in multiple preclinical DIO studies Nimacimab demonstrates durable post-treatment weight loss compared to tirzepatide Nimacimab reduced rebound weight gain following treatment with tirzepatide or nimacimab + tirzepatide Nimacimab outperformed monlunabant head-to-head, and is uniquely positioned as a well-tolerated therapeutic to potentially induce healthier and sustained weight loss, both as a monotherapy, combination and maintenance therapy Top-line data from Phase 2 CBeyond TM study expected to be reported in late Q3/early Q4 2025 SAN DIEGO, Sept

doi: 10.1016/j.molmet.2021.101240 88 LudwigMQChengWGordianDLeeJPaulsenSJHansenSNet al

J Basic Clin Physiol Pharm

Final Thoughts: Treat the Root, Heal the Skin Acne is not just a skin issueits a systemic signal

2 SELECT trial: cardiovascular outcomes The SELECT trial was a landmark study involving over 17,600 people with overweight or obesity and established cardiovascular disease, but without diabetes