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The glomerular capillaries of Bowmans capsule are normally impermeable to proteins due to the electrostatic repulsion generated by negatively charged proteoglycans in the capillary walls (Figure 1)

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In addition, there is the potential for an increased incidence of hypersensitivity reactions such as injection-site reactions

[DOI] [PubMed] [Google Scholar] 127.Carbonell C, Mathew Stephen M, Ruan Y, Warkentin MT, Brenner DR