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It directly stimulates pro-opiomelanocortin/cocaine-and-amphetamine-regulated transcript (POMC/CART) neurons and indirectly inhibits neuropeptide-Y/agouti-related protein (NPY/AgRP) neurons through GABA neurotransmission, reducing appetite and promoting weight loss [40]

Effects of exenatide versus sitagliptin on postprandial glucose, insulin and glucagon secretion, gastric emptying, and caloric intake: a randomized, cross-over study

Their primary indication is the management of type 2 diabetes, where they are used alongside diet and exercise to improve glycaemic control by enhancing insulin secretion, suppressing glucagon, and supporting healthier glucose regulation 3 , 4

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GLP-1 drugs and DPP-4 inhibitors (gliptins) both manage diabetes by controlling metabolism, but the Cleveland Clinic study found that GLP-1 drugs are more potent, have stronger anti-inflammatory properties, and reduce cancer risk more effectively