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Non-GLP-1 agents are most appropriate for patients unable to tolerate GLP-1 medications, those with GLP-1 contraindications (such as personal or family history of medullary thyroid carcinoma), or individuals requiring different metabolic pathways

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While GLP-1RAs uniquely combine pharmacological signaling with reduced nutrient inflow, similar redox constraints may arise in other contexts, including bariatric surgery or intensive dietary interventions

doi: 10.1056/NEJMoa2108269 [DOI] [PubMed] [Google Scholar] 45