glp 1 is not working How GLP-1 weight loss medications work and their limitations GLP-1 Not Working? 5 Mistakes
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Adv Surg

GLP-1s are more effective than other weight-loss drugs, resulting in more weight loss and keeping the weight off
The STEP trials are testing semaglutide at the higher dose of 2.4 mg/week (as compared to 1.0 mg/week for the original diabetes indication), specifically for promoting weight loss, regardless of the presence of type 2 diabetes

Studies have found that GLP-1 promotes neural stem cell proliferation and differentiation, increasing dopaminergic neuron generation by activating PI3K/Akt and MAPK/ERK signaling pathways

Neither insulin nor C-peptide were affected by exenatide treatment in this study