glp 1 agonist with dpp 4 inhibitor DPP4 Inhibitors vs GLP-1 Agonists | June 2021 | Clinical Corner How do SGLT-2 inhibitors, GLP-1

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At present, combination with DPP-4 inhibitors is not recommended, despite the significant glycemic improvement, in view of the enhanced hypoglycemic effects

The gliptins do not significantly modify the pharmacokinetic profile and exposure of other medicines, and vice versa

Chronic high-fat feeding increases GIP and GLP-1 secretion without altering body weight

However, in SURPASS-5, individuals on a background of insulin glargine and tirzepatide reported serious hypoglycemia (19%) more than individuals on a background of insulin glargine and placebo (13%) [14]