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In contrast, trials such as ELIXA, SUSTAIN-6, AMPLITUDE-O, and EXSCEL, which included broader T2DM populations without established CVD, did not show similar MI reductions [15, 17, 19, 23]

By activating GLP-1 receptors, these medications can improve glycemic control and induce a feeling of fullness after small meals

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High leptin levels are linked to high body fat mass