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Tirzepatide appears to produce greater reductions in lean mass than most other therapies, while semaglutide also results in significant muscle loss

2020;9(11):e016704

On January 4, 2026 , Novo Nordisks data exclusivity for semaglutide in Canada also expired the second layer of protection that had been running concurrently with the lapsed patent, and the one that had been preventing generic manufacturers from relying on Novos regulatory data to file their own submissions
