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Orlistat-treated patients ended up having lost 12.8 pounds (5.8 kg), compared to 6.6 pounds (3.0 kg) in those receiving a placebo

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Watch for: Significantly decreased urine output Dark-colored urine that does not improve with hydration Swelling in the ankles or feet Persistent fatigue with decreased urination Semaglutide side effects compared to other GLP-1 medications If you are considering semaglutide versus tirzepatide or evaluating other options, understanding how side effect profiles compare helps inform decision-making

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The Lancet Neurology 17(1):94102