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MEDI0832 (now known as cotadutide) is a balanced co-agonist based on the peptide sequence of glucagon, modified at specific amino acid positions in addition to a palmitic fatty acid side chain to prolong activity

[DOI] [PMC free article] [PubMed] [Google Scholar] 211.Baggio, L

E., Murgatroyd, P

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Therefore, future studies should focus on exploring unknown pathways and their corresponding effects, thereby correlating cellular-level changes with genetic modifications to clarify the relationship between outcomes and functions, which could further facilitate clinical applications