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Meta-analyses have demonstrated that despite an overall benefit, some heterogeneity exists between GLP-1RAs and their effect on stroke

Zepbound (November 2023) for chronic weight management Real-world data : Growing post-market evidence supporting efficacy and safety in diverse populations Cardiovascular outcomes : SURPASS-CVOT trial evaluating cardiovascular endpoints Key Differences Summary# Receptor pharmacology : Retatrutide is a triple agonist (GIP/GLP-1/glucagon)

Liu YK, Ling S, Lui LMW, Ceban F, Vinberg M, Kessing LV, et al

The FDA previously rejected Crexont in June 2023, citing insufficient safety data, as reported by Reuters
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