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Abstract Introduction Recent pharmacological options for weight management include the glucagon-like peptide 1 (GLP-1) receptor agonists semaglutide and liraglutide, and the glucose-dependent insulinotropic polypeptide and GLP-1 receptor agonist tirzepatide, but head-to-head comparisons of all three of these interventions are lacking

However, the MHRA has not analyzed their safety when used outside approved indications like weight loss in individuals who are not overweight or obese

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