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These potential cardioprotective effects may be related to the favourable actions of metformin on lipid metabolism, vascular smooth muscle, hypercoagulation, platelet hyperactivity, cardiomyocyte intracellular calcium handling and endothelial function [24]

(4) Why

Abstract Metformin or glucagon-like peptide-1 (GLP-1) analogue liraglutide has cardiovascular benefits
These benefits were consistent regardless of baseline diabetes [47] or glycemic status [52]

Patients receiving GLP-1RAs were on average younger than patients in the control group (54.6 vs 56.3 years)
