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This emerging evidence underscores the adaptability of certain medications, suggesting they can effectively support recovery from substance use disorders related to alcohol and GLP-1 while also aiding in body mass management

A person fasting for 16 hours might see GLP-1 rise to 812 pmol/L, whereas therapeutic GLP-1 injections maintain steady-state concentrations of 2040 pmol/L or higher, depending on dose

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Importantly, these responses could also be explained by the redundancy of insulinotropic signals from the gut or nervous system during oral versus IP glucose loads, but in the end still demonstrate that -cell GLP-1r, in and of themselves, are not necessary for oral glucose tolerance